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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-7-19
pubmed:abstractText
Diurnal profiles of total and lipoprotein cholesterol and triglycerides were measured in 11 insulin-dependent diabetic subjects without retinopathy, 10 with background and 10 with proliferative retinopathy. The groups were closely matched for age and duration of diabetes. Total cholesterol levels were higher in patients with proliferative (5.6 +/- 0.5 mmol/l) than background (5.1 +/- 0.7 mmol/l) or no retinopathy (4.6 +/- 0.8 mmol/l, trend test; p less than 0.003), due to raised levels of low density lipoprotein (LDL) cholesterol (3.8 +/- 0.9, 3.2 +/- 0.6 and 2.8 +/- 0.8 mmol/l respectively; p less than 0.02). High density lipoprotein (HDL) levels were similar in patients with and without retinopathy and HDL/LDL ratios were lower with more severe retinopathy (p less than 0.025). Cholesterol levels were similar in diabetic subjects without retinopathy and in 12 normal subjects. Triglyceride levels were not related to retinopathy and no measure of plasma lipids correlated with HbA1 or 24-h mean plasma glucose. Total and LDL cholesterol were weakly inversely correlated with creatinine clearance but the association with retinopathy was independent of this effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0012-186X
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-70
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Low density lipoprotein cholesterol: an association with the severity of diabetic retinopathy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't