Cryptococcosis is an often fatal opportunistic fungal infection. Despite efforts to elucidate the role of immunity in host defense against the disease, much remains to be learned. The purpose of this brief review is to provide the reader with an overview of the history of research concerned with host immunity in cryptococcosis. both humoral and cell-mediated studies are included. An effort has been made to present the reader with a comprehensive list of references in the hope of encouraging additional reading and research in this important area.
