Linked Life Data

7035547

Source:http://linkedlifedata.com/resource/pubmed/id/7035547

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1982-4-20
pubmed:abstractText
The technique of biomicroscopic eye examination followed by breeding tests provides a new method for detection of dominant mutations in mice. A total of 11 cataract mutations were found among 17,436 offspring of irradiated male mice. No cataract mutations were observed in 8,174 offspring from the control group. All mutations were phenotypically different. Of the 11 cataract mutations, 3 were semilethal in heterozygous condition, 7 were lethal in homozygous condition, and one presumed mutant was sterile. Seven mutations had complete penetrance whereas penetrance of three mutations was reduced. The rate of dominant mutations affecting an organ system in mice is of main importance for the quantification of the overall genetic damage due to dominant mutations in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0022-1503
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
302-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Dominant cataract mutations detected in offspring of gamma-irradiated male mice.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't