Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1982-4-22
|
| pubmed:abstractText |
Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited or no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents: vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1-triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
535-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7034923-Animals,
pubmed-meshheading:7034923-Antineoplastic Agents,
pubmed-meshheading:7034923-Bone Marrow Transplantation,
pubmed-meshheading:7034923-Cell Line,
pubmed-meshheading:7034923-Child,
pubmed-meshheading:7034923-Disease Models, Animal,
pubmed-meshheading:7034923-Drug Evaluation, Preclinical,
pubmed-meshheading:7034923-Drug Resistance,
pubmed-meshheading:7034923-Female,
pubmed-meshheading:7034923-Humans,
pubmed-meshheading:7034923-Mice,
pubmed-meshheading:7034923-Neoplasm Transplantation,
pubmed-meshheading:7034923-Rhabdomyosarcoma,
pubmed-meshheading:7034923-Sarcoma, Experimental,
pubmed-meshheading:7034923-Thymectomy,
pubmed-meshheading:7034923-Time Factors,
pubmed-meshheading:7034923-Transplantation, Heterologous,
pubmed-meshheading:7034923-Whole-Body Irradiation
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|