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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4529
|
| pubmed:dateCreated |
1982-2-25
|
| pubmed:abstractText |
Cultured human lymphocytes and rat hepatoma cells were labeled with [32P]orthophosphate and the insulin receptor subunits identified by immunoprecipitation and sodium dodecyl sulfate-gel electrophoreses. In both cell types the 95,000-dalton (beta) subunit of the insulin receptor was selectively phosphorylated. Phosphorylation was specifically stimulated by insulin in a dose-dependent fashion after 1 and 15 minutes of hormone treatment, whereas human growth hormone was without effect. This phosphorylation may be a very early event in insulin action.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0036-8075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
8
|
| pubmed:volume |
215
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
185-7
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7031900-Animals,
pubmed-meshheading:7031900-Cells, Cultured,
pubmed-meshheading:7031900-Growth Hormone,
pubmed-meshheading:7031900-Humans,
pubmed-meshheading:7031900-Insulin,
pubmed-meshheading:7031900-Liver Neoplasms, Experimental,
pubmed-meshheading:7031900-Lymphocytes,
pubmed-meshheading:7031900-Macromolecular Substances,
pubmed-meshheading:7031900-Molecular Weight,
pubmed-meshheading:7031900-Phosphorylation,
pubmed-meshheading:7031900-Rats,
pubmed-meshheading:7031900-Receptor, Insulin
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor.
|
| pubmed:publicationType |
Journal Article
|