Linked Life Data

7031849

Source:http://linkedlifedata.com/resource/pubmed/id/7031849

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1982-2-22
pubmed:abstractText
Knowledge of the cytology, ultrastructure and histochemistry of the small intestinal mucosa has advanced considerably over the last 20 years, particularly in regard to the changes associated with coeliac disease. Many of the known structural and cytological changes in coeliac mucosa are probably non-specific, and not directly related to its pathogenesis. It seems important to move away from purely descriptive images of mucosal abnormality such as "villous atrophy', and static measurements, such as crypt-villous ratios. Rather, the mucosa should be viewed as a dynamic, three-dimensional structure and evaluated in terms of total villous cell counts, crypt cell production rates, and so on. The organisation of the lamina propria is still poorly documented, and requires further exploration at the ultrastructural level. More thought should be given to the meaning of mucosal permeability and to its structural counterparts. The immunocytopathology of the coeliac lesion is far from understood; it is questionable whether local humoral activity is central to the pathogenesis of the condition. More needs to be learned of the role of T cells, not only in local mucosal reactions, but also in terms of possible regulatory effects on crypt cell kinetics, villous shape and hence mucosal structure. Increased mitotic activity of epithelial lymphocytes in coeliac disease appears to correlate exclusively with gluten-sensitivity and the use of this presumed immunological marker in the histological diagnosis, and thus prediction, of gluten-sensitised individuals is proposed in this paper.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0085-5928
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
87-106
pubmed:dateRevised
2008-2-13
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Studies of intestinal lymphoid tissue: the cytology and electron microscopy of gluten-sensitive enteropathy, with particular reference to its immunopathology.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't