Linked Life Data

7031726

Source:http://linkedlifedata.com/resource/pubmed/id/7031726

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-2-22
pubmed:abstractText
Cardiovascular effects of infused prostacyclin (PGI2) were investigated in hypertensive anesthetized pigs in the steady state and at 1,2,3,4,5,10,15,20 and 30 min after the beginning of the infusion. PGI2 were perfused at the rate of 2 microgram/Kg/min for 4 min before and after vagosympathectomy. We measured the mean arterial pressure, heart rate, cardiac output, stroke volume, mean pulmonary arterial pressure, mean pulmonary wedge pressure and calculated total systemic resistance and total pulmonary resistance. Our findings suggest that prostacyclin lowers pulmonary and systemic blood pressure in hypertensive animal by vasodilatation. The decrease in mean arterial pressure does not produce any change in heart rate probably because the substance also has a vagal effect. Finally, it might reduce venous return by dilatation of capacitance vessels. PGI2 appears to be a powerful vasodilator agent acting both afterload and preload without influencing heart rate or stroke volume.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0161-4630
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-91
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Prostacyclin effect on blood pressure in pig with aortic obstruction.
pubmed:publicationType
Journal Article