Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1982-2-22
pubmed:abstractText
This study compares the effect of epidermal growth factor and prostaglandins (PGE2 or PGI2), applied topically to gastric mucosa, on gastric secretion and formation of ASA-induced gastric ulcerations in rats. Epidermal growth factor given topically in non-antisecretory doses prevented dose-dependently the formation of ASA-induced ulcers without affecting prostaglandin generation but with a significant rise in DNA synthesis in the oxyntic mucosa. The anti-ulcer effect of topical prostaglandins was also accompanied by an increase in DNA synthesis. This study indicates that topical epidermal growth factor, like PGE2 or PGI2, is cytoprotective and that this cytoprotection is not mediated by the inhibition of gastric secretion or prostaglandin formation but related to the increase in DNA synthesis in oxyntic mucosa.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-1161035, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-13293190, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-13458444, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-14334364, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-361490, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-365666, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-38173, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-456839, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-4601890, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-4636326, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-5479985, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-7450410, http://linkedlifedata.com/resource/pubmed/commentcorrection/7030877-824685
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0017-5749
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
927-32
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Role of mucosal prostaglandins and DNA synthesis in gastric cytoprotection by luminal epidermal growth factor.
pubmed:publicationType
Journal Article