Linked Life Data

7028399

Source:http://linkedlifedata.com/resource/pubmed/id/7028399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-1-9
pubmed:abstractText
Human corneal stroma in situ and keratocyte activity in vitro were studied by the indirect immunofluorescent technique using highly purified antibodies to the various types of collagens, fibronectin and laminin. Studying the localization of the various collagens in situ, it was observed that only type I collagen is present in the human corneal stroma. No positive immunofluorescence is obtained for type II or type III collagen. With type IV collagen, a bright immunofluorescence is observed at the level of Bowman's and Descemet's membranes. However, in vitro, the keratocyte cultures demonstrated the production of both type I and III collagens. No evidence for the production of type II or IV collagens was observed. Along with the collagens, human keratocytes in vitro also produced fibronectin. As for the non collagenous components of basement membrane (laminin), although a positive immunofluorescence was obtained the involvement of other cell-membrane glycoproteins in this reaction is not excluded. The possibility that a deregulation of type III collagen synthesis in vivo might be occurring also during certain pathologies and in corneal wound healing is postulated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0271-3683
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-10
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Collagens and non collagenous proteins in the human eye. I. Corneal stroma in vivo and keratocyte production in vitro.
pubmed:publicationType
Journal Article