Linked Life Data

7025010

Source:http://linkedlifedata.com/resource/pubmed/id/7025010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1981-11-18
pubmed:abstractText
Several of the cellular and molecular interactions of LPS within the experimental host have been examined in an attempt to elucidate the potential role of these interactions in initiating the pathophysiologic events of endotoxemia. Using 125I-LPS, the clearance of LPS from the blood and its tissue, cellular and subcellular localization was established. The H-Mø was found to be the major host site of intravenous LPS localization and, subsequently, the effect of LPS on explanted H-Mø was demonstrated to be both directly cytotoxic and stimulatory of a selective increase in several cellular enzymes. Both the depression in H-Mø function and the stimulation of release of local and systemic mediators by LPS give the H-Mø a potential central role in initiating endotoxemic shock and DIC. Finally, the marked reduction in the clearance rate of LPS remaining in plasma after the initial rapid tissue localization was found to coincide with a density shift to less than 1.2 g/cm3 for the parent LPS. This density shift was found to be dependent upon binding of the LPS to HDL in the serum or plasma and, with the presence of cellular HDL receptors, accounts for a shift in tissue localization to the adrenals. A postulated effect of direct adrenal damage by LPS can thus be invoked as contributing to the endotoxemic syndrome.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
62
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-55
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Interactions of bacterial lipopolysaccharides with tissue macrophages and plasma lipoproteins.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.