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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1981-11-22
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pubmed:abstractText |
We have used highly specific affinity-purified antibodies against mouse kappa- and lambda chains in conjunction with both immunofluorescence analysis on the FACS and enzymatic radioiodination of murine splenocytes and bone marrow cells. Our results indicate that the kappa/lambda ratio of cell surface immunoglobulin is constant during the ontogenetic development of B cells, i.e., a shift in the kappa/lambda ratio does not occur during B cell maturation. Our results suggest that the events controlling kappa and lambda expression on murine B cells are decided very early in ontogeny, before significant antigenic selection.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1670-73
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7024412-Animals,
pubmed-meshheading:7024412-Antibodies,
pubmed-meshheading:7024412-B-Lymphocytes,
pubmed-meshheading:7024412-Bone Marrow,
pubmed-meshheading:7024412-Cell Differentiation,
pubmed-meshheading:7024412-Chemical Precipitation,
pubmed-meshheading:7024412-Chromatography, Affinity,
pubmed-meshheading:7024412-Female,
pubmed-meshheading:7024412-Fluorescent Antibody Technique,
pubmed-meshheading:7024412-Goats,
pubmed-meshheading:7024412-Male,
pubmed-meshheading:7024412-Mice,
pubmed-meshheading:7024412-Mice, Inbred A,
pubmed-meshheading:7024412-Mice, Inbred BALB C,
pubmed-meshheading:7024412-Mice, Inbred CBA,
pubmed-meshheading:7024412-Mice, Inbred DBA,
pubmed-meshheading:7024412-Rabbits,
pubmed-meshheading:7024412-Spleen
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pubmed:year |
1981
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pubmed:articleTitle |
kappa/lambda Shifts do not occur during maturation of murine B cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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