Linked Life Data

7024117

Source:http://linkedlifedata.com/resource/pubmed/id/7024117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-11-22
pubmed:abstractText
The response to spleen cells incompatible at defined histocompatibility, H, loci was studied using the popliteal lymph-node enlargement test to establish its applicability as a method for detecting minor H antigens. This test was able to detect H-2 and H-Y antigens as well as most of the minor H antigens represented by 23 different strains congenic with C57BL/6By. Responses of both naive and immunized recipients were examined, and time-courses of the response were obtained for ten donor strains. These curves revealed that different antigens elicited responses that differed in timing and magnitude of peak enlargements, and that the two parameters were not closely correlated. Both the peak magnitude and the slope of the primary response were correlated with skin-graft rejection, however. The response to individual minor antigens did not appear to be dose-dependent above a threshold. Irradiation of donor cells had strain-dependent effects on the elicited response. Irradiation of recipients appeared to abrogate the primary response but not the responses of previously primed recipients in the combination tested. None of the responses studied had any demonstrable graft-versus-host component.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0093-7711
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
327-37
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Genetics of histocompatibility in mice. III. Characteristics of the popliteal lymph-node response to minor (non-H-2) H antigens.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.