Linked Life Data

7023962

Source:http://linkedlifedata.com/resource/pubmed/id/7023962

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1981-11-18
pubmed:abstractText
3- or 14-month-old female rats were intravenously injected N-nitroso-N-methylurea (MNU), 50 mg/kg body weight, 2 or 4 times weekly. There was a direct correlation between the incidence of mammary carcinomas and MNU doses. Kidney tumors occurred inversely proportional to the dose of the carcinogen. Mammary adenocarcinomas were only observed in young MNU-treated rats. Cervicovaginal malignant tumors were only observed in old MNU-treated rats. The incidence of hematopoietic system tumors was the same in animals of both age groups. Rats treated with MNU showed acceleration of benign spontaneous tumor development. The effect of aging on the initial stage of MNU-induced carcinogenesis is believed to be determined by age-associated changes in the proliferative activity of target tissues. The effect of aging on the further development of carcinogenesis may be caused by age-associated hormonal, metabolic, and immunological shifts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0232-1513
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-90
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Carcinogenesis and aging. I. Modifying effects of aging on N-methyl-N-nitrosourea-induced carcinogenesis in female rats.
pubmed:publicationType
Journal Article