Linked Life Data

7023166

Source:http://linkedlifedata.com/resource/pubmed/id/7023166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1981-10-14
pubmed:abstractText
We studied the efficacy of cimetidine or placebo in relieving ulcer pain on 27 endoscopically-proven gastric ulcer outpatients in a randomized controlled prospective double blind trial. There were 12 patients in the cimetidine (1,200 mg daily) treated group and 15 patients in the placebo treated group. No antacid was allowed, but a placebo antacid with no neutralizing capacity was given as needed for pain. The incidence of complete pain relief at 2 and 4 weeks was 58% and 67% in the cimetidine treated patients, and 60% and 80% in the placebo treated patients. At 6 weeks of treatment there was no increase in the number of patients with complete pain relief in either group. There was no significant difference between the 2 groups in the incidence of ulcer pain relief at any of the 3 observation periods. Gastric ulcer healing rates and gastric ulcer pain relief were compared at 2 and 4 weeks. The cimetidine treated group healed 17% with 58% pain relief, and the placebo treated group had no ulcers healed at 2 weeks with 60% complete pain relief. There was no statistical association between ulcer healing and pain relief in both treatment groups at the 2 week evaluation period, but there was statistical association (P less than .05) at 4 weeks. The results of this study demonstrated that in gastric ulcer outpatients treated for 6 weeks: 1) the complete relief of gastric ulcer pain is not influenced by treatment with cimetidine when compared to placebo, and 2) there is no association between complete pain relief and the presence of an endoscopically proven gastric ulcer during the first 2 weeks of treatment with either cimetidine or placebo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9033
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Cimetidine vs placebo: complete gastric ulcer pain relief. Six week controlled double blind study without any antacid therapy.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial