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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-9-22
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pubmed:abstractText |
The present study was undertaken to investigate if the suppressed cell-mediated immune responses observed in dengue type 2 virus (DV)-infected mice could be due to the cytotoxic factor (CF) produced in the spleens of DV-infected mice. We have observed that CF given intravenously (i.v.) kills splenic cells and reduces the total cells in the spleen. Mice treated with CF have a significantly depressed immune response to sheep erythrocytes, viz. delayed-type-hypersensitivity as measured by footpad swelling reaction at 24 hr; Jerne's antibody plaque-forming cells in the spleen; and migration inhibition of spleen cells in presence of antigen. These findings are similar to those seen earlier in DV-infected mice.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-6
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:7019053-Animals,
pubmed-meshheading:7019053-Cell Migration Inhibition,
pubmed-meshheading:7019053-Cytotoxicity, Immunologic,
pubmed-meshheading:7019053-Dengue Virus,
pubmed-meshheading:7019053-Erythrocytes,
pubmed-meshheading:7019053-Hemolytic Plaque Technique,
pubmed-meshheading:7019053-Hypersensitivity, Delayed,
pubmed-meshheading:7019053-Immunity, Cellular,
pubmed-meshheading:7019053-Immunosuppression,
pubmed-meshheading:7019053-Leukocytes,
pubmed-meshheading:7019053-Mice,
pubmed-meshheading:7019053-Spleen
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pubmed:year |
1981
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pubmed:articleTitle |
Dengue virus-induced cytotoxic factor suppresses immune response of mice to sheep erythrocytes.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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