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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1978-12-29
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pubmed:abstractText |
The binding of the synthetic immunoadjuvant N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP, for muramyl dipeptide) to human and rabbit sera containing peptidoglycan (PG) antibodies was investigated. Studies were performed by employing the corresponding 14C or 125I-labeled compounds in Farr-type binding and inhibition assays. Whereas MDP did not react with naturally occurring or experimentally induced PG-antibodies, the analog of MDP MDP-L-Lys-D-Ala did bind to hyperimmune rabbit anti-PG sera, but not to the human sera tested. These studies indicate that the radioimmunoassays employed basically are applicable for the selection of nonimmumogenic MDP analogs possessing immunoadjuvant activity.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1219-22
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:701793-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:701793-Adjuvants, Immunologic,
pubmed-meshheading:701793-Animals,
pubmed-meshheading:701793-Antibodies,
pubmed-meshheading:701793-Binding, Competitive,
pubmed-meshheading:701793-Binding Sites, Antibody,
pubmed-meshheading:701793-Glycopeptides,
pubmed-meshheading:701793-Humans,
pubmed-meshheading:701793-Immune Sera,
pubmed-meshheading:701793-Peptidoglycan,
pubmed-meshheading:701793-Rabbits
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|
pubmed:year |
1978
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|
pubmed:articleTitle |
Absence of binding of MDP, a synthetic immunoadjuvant, to anti-peptidoglycan antibodies.
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pubmed:publicationType |
Journal Article
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