Linked Life Data

7017343

Source:http://linkedlifedata.com/resource/pubmed/id/7017343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1981-8-27
pubmed:abstractText
To assess the effects of mild hyperinsulinemia on the metabolic adaptations to exercise, five normal male subjects were studied during 2 cycles of 30 min rest followed by 60 min mild exercise. During one cycle, insulin was infused at a rate of 0.33 mU/kg/min. During both cycles, plasma glucose concentration was kept constant by a glucose-controlled glucose infusion system. Studies with and without insulin were performed in random order, with 30 min between studies. During the insulin infusion, plasma non-esterified fatty acids fell during rest and failed to rise with exercise, indicating a limited availability of this substrate to working muscle. Insulin infusion also inhibited the expected rise in glycerol and 3-hydroxybutyrate normally observed during exercise. Plasma lactate concentrations at the completion of exercise with insulin infusion were higher than after exercise without insulin infusion. Greater metabolic dependence on carbohydrate metabolism is suggested by an increased respiratory quotient during insulin infusion. Insulin infusion had no significant effect on the amount of glucose which needed to be infused for maintaining a constant plasma glucose during rest, but there was a large and significant difference in the need for infused glucose during exercise with and without insulin infusion. The results indicate that even mild hyperinsulinism interferes with normal metabolic responses to exercise, and suggest that fall in insulin concentration seen with exercise is an important regulatory process, not merely a secondary consequences of a declining plasma glucose level.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0026-0495
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
688-94
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Effects of mild hyperinsulinemia on the metabolic response to exercise.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial