Linked Life Data

7015610

Source:http://linkedlifedata.com/resource/pubmed/id/7015610

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-7-20
pubmed:abstractText
The effect of cyclosporin A was tested in a heterotopic cardiac xenograft model, in which hamster hearts were implanted into LEW rats. Despite the presence of low titers of rat anti-hamster lymphocytotoxic antibodies immediate rejection of the hamster hearts did not occur, suggesting that this model represented a xenogeneic barrier of moderate strength, compatible with the close relationship of the two species. Cyclosporin A, in doses approaching toxic levels of 35 or 50 mg/kg/day for 14 days, prolonged function of the cardiac xenografts for median survival times of 21 and 11 days, respectively, in contrast to the median survival of 2 days in untreated recipients. The lymphocytotoxic antibody response of the LEW rats to the cardiac xenograft was suppressed, even in doses that did not prolong graft survival. Only the dose of 50 mg/kg/day produced any significant alteration in the histological features of rejection in the cardiac xenografts. Although cyclosporin A markedly prolonged survival of cardiac xenografts between these two closely related species, the requirement of virtually toxic levels of the drug for an effect do not suggest that this drug will be of value in transplantation of vascularized organ xenografts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0041-1337
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
164-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Prolongation of cardiac xenograft survival in rats receiving cyclosporin A.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't