Linked Life Data

7012840

Source:http://linkedlifedata.com/resource/pubmed/id/7012840

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1981-6-13
pubmed:abstractText
Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and intravenous glucose administration. The body weights, ages, and sexes of the subjects were well matched with those of control subjects with normal tolerances to oral and intravenous glucose administration. Computer analysis of the glucose and insulin curves during a standardized glucose infusion test made possible the measurement of the initiatory (parameters KI and IP) and potentiatory (parameter KP) effects of glucose on insulin release and of the sensitivity to endogenous insulin (parameter KG). In subjects with impaired oral but normal intravenous glucose tolerance tests, KG was decreased, KP was increased, and KI and IP were normal. However, in these subjects, KI and IP were considerably lower than in a matched group of control subjects with the same decrease in KG but with normal oral and intravenous glucose tolerance tets. In subjects in which both oral and intravenous glucose tolerance tests were impaired and in subjects with mild manifest diabetes, KI, IP, and KG were decreased whereas KP was normal. These data suggest that all stages of glucose intolerance are accompanied by a decreased ability of glucose to initiate insulin release and by decreased sensitivity to insulin. These derangements seem to be partially compensated for by enhancement of the capacity of glucose to potentiate insulin release in subjects with decreased oral but normal intravenous glucose tolerance tests.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-13443758, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-13464070, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-13952078, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-383594, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-4424575, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-4880964, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-5216975, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-5338206, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-5630505, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-6023769, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-6068654, http://linkedlifedata.com/resource/pubmed/commentcorrection/7012840-814810
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7425-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Insulin release, insulin sensitivity, and glucose intolerance.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't