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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1978-12-20
|
| pubmed:abstractText |
Tracheal tumors were induced by repeated intratracheal exposures to the carcinogen N-nitroso-N-methylurea (NMU), using a catheter system previously described. Carcinogen concentrations of 0.25, 0.50 and 1.0% were employed in 20 or 30 twice-weekly exposures. Most of the tumors developed in the mid-portion of the tracheas. Virtually all tumors developed after the end of the 10- to 15-week exposure period. Tumor incidence ranged from 20-94% with mean tumor induction times of 13-46 weeks, depending on NMU concentration and frequency of exposure (i.e., dose). At lower doses, mostly non-invasive tumors were induced; at higher doses, mostly invasive carcinomas of various histological types (epidermoid, adeno-, epidermoid-adeno, and anaplastic large- and small-cell carcinomas) were induced. Adenocarcinomas were most frequent at low NMU concentrations. The possible mechanisms of the carcinogen dose effects are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
298-303
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:700892-Adenocarcinoma,
pubmed-meshheading:700892-Animals,
pubmed-meshheading:700892-Atrophy,
pubmed-meshheading:700892-Carcinoma, Squamous Cell,
pubmed-meshheading:700892-Carcinoma in Situ,
pubmed-meshheading:700892-Cricetinae,
pubmed-meshheading:700892-Dose-Response Relationship, Drug,
pubmed-meshheading:700892-Hyperplasia,
pubmed-meshheading:700892-Male,
pubmed-meshheading:700892-Mesocricetus,
pubmed-meshheading:700892-Metaplasia,
pubmed-meshheading:700892-Methylnitrosourea,
pubmed-meshheading:700892-Neoplasms, Experimental,
pubmed-meshheading:700892-Nitrosourea Compounds,
pubmed-meshheading:700892-Precancerous Conditions,
pubmed-meshheading:700892-Time Factors,
pubmed-meshheading:700892-Trachea,
pubmed-meshheading:700892-Tracheal Neoplasms
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Effects of carcinogen dose on the characteristics of the tracheal tumor response induced by N-nitroso-N-methylurea in hamsters.
|
| pubmed:publicationType |
Journal Article
|