|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1981-3-17
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|
pubmed:abstractText |
To study the efficacy of corticosteroids in chronic active hepatitis (CAH) positive for hepatitis B surface antigen (HBsAg), we pair-randomized 51 patients to receive either 15 to 20 mg of prednisolone per day or a placebo. After initial remission, the maintenance dosage of prednisolone was 10 mg per day, and the patients were prospectively followed for up to 3 1/2 years. Prednisolone decreased serum bilirubin (P < 0.05) and globulin (P < 0.01) at three months; it delayed other biochemical remission occurring after the second month of medication (P < 0.001); it hastened biochemical relapse (P < 0.0001); and it increased the frequency of complications (P < 0.0001) and the death rate (P < 0.01). We conclude that prednisolone has an overall harmful effect in patients with HBsAg-positive CAH.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Feb
|
|
pubmed:issn |
0028-4793
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
12
|
|
pubmed:volume |
304
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
380-6
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|
pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7005678-Adult,
pubmed-meshheading:7005678-Alanine Transaminase,
pubmed-meshheading:7005678-Aspartate Aminotransferases,
pubmed-meshheading:7005678-Bilirubin,
pubmed-meshheading:7005678-Chronic Disease,
pubmed-meshheading:7005678-Clinical Trials as Topic,
pubmed-meshheading:7005678-Female,
pubmed-meshheading:7005678-Hepatitis,
pubmed-meshheading:7005678-Hepatitis B,
pubmed-meshheading:7005678-Hepatitis B Surface Antigens,
pubmed-meshheading:7005678-Humans,
pubmed-meshheading:7005678-Male,
pubmed-meshheading:7005678-Middle Aged,
pubmed-meshheading:7005678-Prednisolone,
pubmed-meshheading:7005678-Prospective Studies,
pubmed-meshheading:7005678-Random Allocation,
pubmed-meshheading:7005678-Remission, Spontaneous,
pubmed-meshheading:7005678-Serum Globulins
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|
pubmed:year |
1981
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|
pubmed:articleTitle |
Deleterious effect of prednisolone in HBsAg-positive chronic active hepatitis.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Case Reports,
Research Support, Non-U.S. Gov't
|
