| pubmed-article:7002187 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7002187 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:7002187 | lifeskim:mentions | umls-concept:C0002586 | lld:lifeskim |
| pubmed-article:7002187 | lifeskim:mentions | umls-concept:C0012586 | lld:lifeskim |
| pubmed-article:7002187 | lifeskim:mentions | umls-concept:C1449668 | lld:lifeskim |
| pubmed-article:7002187 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:7002187 | lifeskim:mentions | umls-concept:C0072245 | lld:lifeskim |
| pubmed-article:7002187 | pubmed:dateCreated | 1981-2-19 | lld:pubmed |
| pubmed-article:7002187 | pubmed:abstractText | 1 Propyphenazone 220 mg was administered orally to volunteers. Maximum plasma concentrations between 1.5 microgram/ml and 3.5 micrograms/ml were found 30 min later. After comparable doses plasma concentrations in dog and rabbit were lower. The distribution volumes were 2 l/kg. 2 The major metabolic route of propyphenazone is demethylation. The main urinary metabolite is the enolglucuronide of N-(2)-demethylpropyphenazone. 3 Aminopyrine is rapidly and almost completely absorbed after oral administration. Maximum plasma concentrations of 10 microgram/ml are reached 1.5 h after a 500 mg dose. The biological half-life is 2-3 h, the relative distribution volume 60% on average, and binding to plasma proteins approximately 15%. 4 Unchanged aminopyrine is only excreted in small quantities. The major routes of metabolism are demethylation (4-methylaminoantipyrine and 4-aminoantipyrine) and acylation (4-acetyl and 4-formylaminoantipyrine). There are other biotransformation products. 5 After oral administration of [14C]-dipyrone 480 mg the maximum serum concentration of 13.4 +/- 0.8 microgram/ml occurred at 1-1.5 hours. 6 Dipyrone was not detectable in serum or urine. Four of seven metabolites were identified, and were identical with the main metabolites of aminopyrine. | lld:pubmed |
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| pubmed-article:7002187 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7002187 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7002187 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7002187 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7002187 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7002187 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7002187 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:7002187 | pubmed:author | pubmed-author:VolzMM | lld:pubmed |
| pubmed-article:7002187 | pubmed:author | pubmed-author:KellnerH MHM | lld:pubmed |
| pubmed-article:7002187 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7002187 | pubmed:volume | 10 Suppl 2 | lld:pubmed |
| pubmed-article:7002187 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7002187 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7002187 | pubmed:pagination | 299S-308S | lld:pubmed |
| pubmed-article:7002187 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7002187 | pubmed:meshHeading | pubmed-meshheading:7002187-... | lld:pubmed |
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| pubmed-article:7002187 | pubmed:meshHeading | pubmed-meshheading:7002187-... | lld:pubmed |
| pubmed-article:7002187 | pubmed:meshHeading | pubmed-meshheading:7002187-... | lld:pubmed |
| pubmed-article:7002187 | pubmed:meshHeading | pubmed-meshheading:7002187-... | lld:pubmed |
| pubmed-article:7002187 | pubmed:meshHeading | pubmed-meshheading:7002187-... | lld:pubmed |
| pubmed-article:7002187 | pubmed:meshHeading | pubmed-meshheading:7002187-... | lld:pubmed |
| pubmed-article:7002187 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7002187 | pubmed:articleTitle | Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone). | lld:pubmed |
| pubmed-article:7002187 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7002187 | pubmed:publicationType | Review | lld:pubmed |
