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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1981-2-19
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pubmed:abstractText |
1 Propyphenazone 220 mg was administered orally to volunteers. Maximum plasma concentrations between 1.5 microgram/ml and 3.5 micrograms/ml were found 30 min later. After comparable doses plasma concentrations in dog and rabbit were lower. The distribution volumes were 2 l/kg. 2 The major metabolic route of propyphenazone is demethylation. The main urinary metabolite is the enolglucuronide of N-(2)-demethylpropyphenazone. 3 Aminopyrine is rapidly and almost completely absorbed after oral administration. Maximum plasma concentrations of 10 microgram/ml are reached 1.5 h after a 500 mg dose. The biological half-life is 2-3 h, the relative distribution volume 60% on average, and binding to plasma proteins approximately 15%. 4 Unchanged aminopyrine is only excreted in small quantities. The major routes of metabolism are demethylation (4-methylaminoantipyrine and 4-aminoantipyrine) and acylation (4-acetyl and 4-formylaminoantipyrine). There are other biotransformation products. 5 After oral administration of [14C]-dipyrone 480 mg the maximum serum concentration of 13.4 +/- 0.8 microgram/ml occurred at 1-1.5 hours. 6 Dipyrone was not detectable in serum or urine. Four of seven metabolites were identified, and were identical with the main metabolites of aminopyrine.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-1016602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-1164816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-1182870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-1238541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-13643508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-14309171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-14344149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-15415037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-15437290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-239546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4119355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4366427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4419027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4643487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4657976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4702492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4702493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-4801687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-5324709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-5348404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-5464171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-5530451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-580401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-582774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-721928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-913279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-936642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7002187-965130
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10 Suppl 2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299S-308S
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7002187-Administration, Oral,
pubmed-meshheading:7002187-Aminopyrine,
pubmed-meshheading:7002187-Animals,
pubmed-meshheading:7002187-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:7002187-Antipyrine,
pubmed-meshheading:7002187-Biotransformation,
pubmed-meshheading:7002187-Dipyrone,
pubmed-meshheading:7002187-Humans,
pubmed-meshheading:7002187-Kinetics,
pubmed-meshheading:7002187-Oxidation-Reduction,
pubmed-meshheading:7002187-Pyrazoles,
pubmed-meshheading:7002187-Suppositories
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pubmed:year |
1980
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pubmed:articleTitle |
Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone).
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pubmed:publicationType |
Journal Article,
Review
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