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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1981-1-26
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pubmed:abstractText |
The in vivo function of the gene 2 protein of bacteriophage T7 has been examined. The gene 2 protein appears to modulate the activity of the gene 3 endonuclease in order to prevent the premature degradation of any newly-formed DNA concatemers. This modulation is not however a direct interacton between the two proteins. In single-burst experiments rifamycin can substitute for the gene 2 protein, allowing formation of fast-sedimenting replicative DNA intermediates and progeny phage production. This suggests that the sole function of the gene 2 protein is inhibition of the host RNA polymerase and that the latter enzyme directs or promotes the endonucleolytic action of the gene 3 protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-1095770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-1133879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-1146231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-338932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-387768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-388419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4262658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4507727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4554613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4557205,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4567741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4586410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4604641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4760132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4902069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4922040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4922041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-4993001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-5346051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-5723746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-6997508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7001361-853564
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3043-53
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1980
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pubmed:articleTitle |
The role of bacteriophage T7 gene 2 protein in DNA replication.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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