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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1981-1-16
|
| pubmed:abstractText |
Measurements of active and acid-activatable renin concentrations and renin substrate concentrations in plasma and endometrial samples taken from 31 patients are described. All of these patients were taking oestrogen-containing oral contraceptive preparations. Plasma active renin concentration was lower in these cycles than in normal cycles and the substrate concentrations higher. In the endometrium the concentrations of all of the components of the system were raised by oral contraceptives. As with normal cycles, the maximum potential for production of the angiotensins was in the premenstrual stage of the cycle. It is suggested that this increase in potential is associated with the onset of menstruation.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Cardiovascular Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Comparative Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Contraception,
http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Methods,
http://linkedlifedata.com/resource/pubmed/keyword/Endometrial Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Endometrium,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Female,
http://linkedlifedata.com/resource/pubmed/keyword/HOMEOSTASIS,
http://linkedlifedata.com/resource/pubmed/keyword/Menstruation,
http://linkedlifedata.com/resource/pubmed/keyword/Oral Contraceptives,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Renin-angiotensin-aldosterone Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System,
http://linkedlifedata.com/resource/pubmed/keyword/Uterus
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0306-5456
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
883-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:otherAbstract |
PIP: This study compared plasma and endometrial active and acid activatable renin and renin substrate in women taking oral contraceptives with results obtained previously in women with normal spontaneous menstrual cycles. Plasma and endometrial samples were taken from 31 women who were taking estrogen-containing oral contraceptives. Results are presented in 8 groups of menstrual cycle stages (menstruation, 3 proliferative, 3 secretory, and premenstrual phases). In cycles controlled by the pill, plasma renin throughout the cycle remained between 80 and 230 mcU/ml. No statistical differences in plasma renin throughout the cycle could be found among the 8 menstrual phase groups. For endometrial active iso-renin the scatter of results was large, but no significant differences were found (concentration remained from 410-1030 mcU/ml). Plasma acid-activatable renin concentration was from 100-200 mcU/ml for most of the cycle, but a significant increase (P .05) occurred in late secretory stage. Endometrial acid-activating iso-renin remained fairly constant. Estrogens exerted a profound effect on plasma substrate. In premenstrual, menstrual, and early proliferative stages the concentrations were between .8 and 1 mmol/ml; in the rest of the cycle, these values rose to 1.6-2.2 (P .01). The same was true in the endometrium where the increase in substrate concentration in the premenstrual stage was significant (P .05).
|
| pubmed:meshHeading |
pubmed-meshheading:7000163-Angiotensinogen,
pubmed-meshheading:7000163-Angiotensins,
pubmed-meshheading:7000163-Contraceptives, Oral,
pubmed-meshheading:7000163-Endometrium,
pubmed-meshheading:7000163-Female,
pubmed-meshheading:7000163-Humans,
pubmed-meshheading:7000163-Menstruation,
pubmed-meshheading:7000163-Renin
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Renin substrate, active and acid-activatable renin concentrations in human plasma and endometrium during menstrual cycles controlled by oral contraceptive preparations.
|
| pubmed:publicationType |
Journal Article
|