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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1980-9-28
|
| pubmed:abstractText |
Hapten-specific receptor material can be isolated from sensitized murine T and B lymphocytes by the use of hapten-coupled nylon discs. The structural element shared between T and B cell receptors is the variable region of immunoglobulin heavy chains (VH), while known constant immunoglobulin domains appear not to be part of the T cell receptor molecule. The rules governing VH expression (i.e. NPb-idiotype expression) in the B and the T cell compartments are, however, different. Allotype-linked VH (idiotype) expression on T cell molecules was used in genetic reconstitution experiments to prove that the material under study is an endogenous T cell product. With the data available it seems reasonable to view the T cell molecules as representing surface receptors for antigen although this point needs further investigation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0361-7742
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
345-58
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1980
|
| pubmed:articleTitle |
Antigen-specific receptor molecules isolated from murine T lymphocytes.
|
| pubmed:publicationType |
Journal Article,
Review
|