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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1980-9-26
|
| pubmed:abstractText |
The capacity of the T cell mitogens phytohemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM), and Staphylococcus protein A (SpA) to induce B cell proliferation and differentiation was compared with the B cell mitogen, formalinized Staphylococcus aureus (STA). Lymphocyte subpopulations from normal donors and patients with various immunodeficiency diseases were studied. In the presence of the T cell mitogens, irradiated T cells were capable of providing a helper cell activity that enabled co-cultured B lymphocytes to proliferate in response to these mitogens and to differentiate into IgM-secreting (direct) hemolytic plaque-forming cells (PFC). In the PFC response, radioresistant T-helper and radiosensitive T-suppressor cell activities could be demonstrated. T-suppressor cell activity outweighed helper activity only in nonirradiated co-cultures stimulated with Con A. Patients with severe combined immunodeficiency lacked mitogen-induced helper T cells, whereas patients with various forms of humoral immune deficiency were normal in this respect. These findings and the tissue distribution of the helper activity is aquired early in post-thymic T cell differentiation. The data suggest that experiments with cell lineage-specific lymphocyte mitogens should be considered in the context of more complex cell-cell interactions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
125
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
827-32
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:6993564-B-Lymphocytes,
pubmed-meshheading:6993564-Cell Differentiation,
pubmed-meshheading:6993564-Hemolytic Plaque Technique,
pubmed-meshheading:6993564-Humans,
pubmed-meshheading:6993564-Lymphocyte Activation,
pubmed-meshheading:6993564-Lymphocyte Cooperation,
pubmed-meshheading:6993564-Mathematics,
pubmed-meshheading:6993564-Mitogens,
pubmed-meshheading:6993564-Palatine Tonsil,
pubmed-meshheading:6993564-Spleen,
pubmed-meshheading:6993564-T-Lymphocytes,
pubmed-meshheading:6993564-Thoracic Duct
|
| pubmed:year |
1980
|
| pubmed:articleTitle |
Polyclonal activation of human lymphocytes in vitro-II. Reappraisal of T and B cell-specific mitogens.
|
| pubmed:publicationType |
Journal Article
|