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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1980-9-26
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pubmed:abstractText |
Unlike macrophages from responsive mouse strains, peritoneal cells of P/J mice treated in vivo with viable Mycobacterium bovis, strain BCG, or killed Corynebacterium parvum fail to develop tumoricidal activity. P/J macrophages treated in vitro with lymphokine-rich supernatants, bacterial endotoxic lipopolysaccharides (LPS) or T cell mitogens also fail to develop cytotoxic activity. Experimental manipulation of effector:target cell ratios, doses of activation stimuli, or tumor target cells did not evoke cytotoxic activity. The macrophage defect of P/J mice appeared similar to that of lipid A-insensitive C3H/HeJ mice. The macrophage defect of C3H/HeJ mice is controlled by a gene identical or closely linked to the Lpsd gene. Tumoricidal defects of P/J macrophages, however, appeared independent of the Lpsd gene: responses of P/J spleen cells or macrophages to LPS, which are controlled by the Lps gene, were normal. P/J mice therefore represent a distinct and potentially useful genetic probe for characterization of mechanisms in macrophage activation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
771-6
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:6993562-Animals,
pubmed-meshheading:6993562-Chemotaxis,
pubmed-meshheading:6993562-Cytotoxicity, Immunologic,
pubmed-meshheading:6993562-Inflammation,
pubmed-meshheading:6993562-Lipopolysaccharides,
pubmed-meshheading:6993562-Lymphokines,
pubmed-meshheading:6993562-Macrophages,
pubmed-meshheading:6993562-Mice,
pubmed-meshheading:6993562-Mice, Inbred C3H,
pubmed-meshheading:6993562-Mycobacterium bovis,
pubmed-meshheading:6993562-Phagocytosis,
pubmed-meshheading:6993562-Propionibacterium acnes
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pubmed:year |
1980
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pubmed:articleTitle |
Defective tumoricidal capacity of macrophages from P/J mice: characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli.
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pubmed:publicationType |
Journal Article
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