Linked Life Data

6990955

Source:http://linkedlifedata.com/resource/pubmed/id/6990955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1980-8-28
pubmed:abstractText
Human monospecific HLA B27 typing sera have been shown to have increased binding activity for klebsiella extracts by haemagglutination (P less than 0.001), radiobinding assay (P less than 0.025) and radiolabelled antigen competition assay (P less than 0.02) when compared to non-B27 tissue typing sera. These observations are in agreement with those of studies using rabbit sera, suggesting that HLA B27 lymphocytes may exhibit partial cross-reactivity with bacterial antigens found in some Gram-negative microorganisms such as klebsiella. It is suggested ankylosing spondylitis may occur as a result of immunological damage following infection by Gram-negative bacteria carrying antigens having stereochemical similarity to self antigens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1021
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
92-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Ankylosing spondylitis, HLA-B27 and Klebsiella. II. Cross-reactivity studies with human tissue typing sera.
pubmed:publicationType
Journal Article