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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1980-7-28
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pubmed:abstractText |
Phytohemagglutinin (PHA)-induced cytotoxicity against adherent HeLa cells, a reproducible test for primary T cell cytotoxicity, was used in the followup of 34 renal transplant recipients and related to the outcome. During the 1st week, two uncomplicated cases showed a decrease in cytotoxicity of more than 20% and it remained low. One patient with a cytomegalovirus (CMV) infection showed a marked increase in cytotoxicity (37%) and it remained high. In 31 patients with a rejection episode, a change of -20 to +20% was observed. During the 2nd week, all 10 patients who developed an irreversible rejection showed an increase of more than 20% (mean, 29 +/- 8%), in contrast to only 2 of 21 patients with a reversible rejection (mean, -1 +/- 15%, P less than 0.001). There were no differences between these two groups in lymphocyte and T lymphocyte counts, or in prednisone or azathioprine dose or blood urea nitrogen levels. These results indicate that regular assessment of PHA-induced cytotoxicity may be useful in the followup of renal transplant patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-1337
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
357-60
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6990559-Cytotoxicity, Immunologic,
pubmed-meshheading:6990559-Graft Rejection,
pubmed-meshheading:6990559-Graft Survival,
pubmed-meshheading:6990559-Humans,
pubmed-meshheading:6990559-Kidney,
pubmed-meshheading:6990559-Kidney Transplantation,
pubmed-meshheading:6990559-Leukocyte Count,
pubmed-meshheading:6990559-Lymphocytes,
pubmed-meshheading:6990559-Lymphopenia,
pubmed-meshheading:6990559-Phytohemagglutinins,
pubmed-meshheading:6990559-T-Lymphocytes,
pubmed-meshheading:6990559-Time Factors,
pubmed-meshheading:6990559-Transplantation Immunology,
pubmed-meshheading:6990559-Virus Diseases
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pubmed:year |
1980
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pubmed:articleTitle |
Differentiation between irreversible and reversible rejection in renal transplant patients by monitoring of phytohemagglutinin-induced cytotoxicity.
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pubmed:publicationType |
Journal Article
|