Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1980-7-12
pubmed:abstractText
The products of the lexA and recA genes of Escherichia coli regulate the cellular response to DNA damage (the SOS response). Here we describe the cloning of the wild-type lexA gene and the identification of its 24,000-dalton protein product. We also describe construction, by recombination in vitro, of a phage that bears the lexA promoter fused to the lacZ gene. Experiments with this fusion phage and with multicopy plasmids that carry the lexA gene showed that the lexA gene product represses of its own promoter. This repression occurs even if the cell has no recA gene, showing that the lexA protein need not be complexed to the recA protein for activity. Moreover, the presence of multicopy plasmids that carry the lexA gene blocks expression of all SOS responses tested. This presumably results from two effects: (i) repression of the recA gene, the product of which is required to activate many of these responses; and (ii) direct repression of other functions involved in the SOS response.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-1061069, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-1069307, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-1097429, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-1107802, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-1195397, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-15305587, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-158477, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-160562, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-163812, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-319458, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-325391, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-338917, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-341151, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-344136, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-353034, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-368030, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-368040, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-370836, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-4205905, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-4600265, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-4866981, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-4941551, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-5015426, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-737195, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-765739, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-785206, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-788919, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-795416, http://linkedlifedata.com/resource/pubmed/commentcorrection/6990417-959843
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1932-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
The lexA gene product represses its own promoter.
pubmed:publicationType
Journal Article