Linked Life Data

698952

Source:http://linkedlifedata.com/resource/pubmed/id/698952

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11 Pt 2
pubmed:dateCreated
1978-12-27
pubmed:abstractText
A testable hypothesis for the role of hormones in mammary carcinogenesis with implications for other endocrine-related carcinogenesis is presented. The hypothesis is based on these observations: (a) hormones are involved, directly or indirectly, in regulating cell division in normal mammary cells: (b) emergence of overt mammary tumors requires hormonal stimulation of cells receiving carcinogenic stimulus; (c) normal mammary cells are of finite divisional capabilities, whereas neoplastic cells appear to have infinite divisional life; and (d) normal cells, when present in large quantities relative to the neoplastic cells, inhibit the growth of the latter cells. According to the hypothesis hormones play at least two roles in mammary carcinogenesis induced by diverse agents, such as viruses, chemicals, and radiation. First, hormones are necessary for DNA synthesis and mitosis of initial transformed cells for their conversion into fixed transformed cells with heritable characteristics. Second, hormones, by increasing the rate of cell division, shorten the reproductive life span of normal cells, eventually causing a reduction in the normal to transformed cell ratio in the population--a condition that allows the emergence of tumor cells by overriding the inhibitory influence of normal cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4046-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Role of hormones in mammary neoplasia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.