Linked Life Data

6989243

Source:http://linkedlifedata.com/resource/pubmed/id/6989243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1980-6-16
pubmed:abstractText
With a sensitive indirect immunofluorescent technique, we studied the antibody response to Candida albicans in 150 human amniotic fluid (AF) specimens at 15 to 18 weeks' gestation. Specific IgG was detected in 94.7% of the samples and specific IgA, in 98%, while 1.3% were negative in both tests. A comparison of the mean ratio of anticandidal titers (IgA/IgG) in AF and human serum indicated a predominance of IgA activity in AF and the reverse in serum (2.01 versus 0.66, p less than 0.001). There was no correlation between IgG and corresponding IgA titers, which supports the fetal origin of IgA. Humoral immunity alone had no discernible influence on the growth of C. albicans in midtrimester AF. It is suggested that the synthesis of specific IgA is genetically determined because it presumably offers some functional advantage over transmitted maternal IgG in the local defensive mechanisms of the amniotic cavity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9378
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1075-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Natural occurrence of a humoral response to Candida in human amniotic fluid.
pubmed:publicationType
Journal Article