Linked Life Data

6988605

Source:http://linkedlifedata.com/resource/pubmed/id/6988605

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1980-6-27
pubmed:abstractText
We have previously described the isolation of a lipoidal splenic extract (LSE) that demonstrated a variety of hematologic effects including inhibition of platelet aggregation both in vivo and in vitro. Since endotoxin causes platelet aggregation and microembolism the protective effect of LSE in endotoxemia was examined in the present study. Both young and elderly Swiss mice given LSE 2--3 hours before endotoxin challenge showed a statistically significant increase in survival compared with saline-treated controls. However, no significant improvement in survival was noted when LSE was administered at the same time as endotoxin. These results add further support to the role of the spleen in the control of infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-5282
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
410-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Protective effect of a splenic extract in mice with endotoxemia.
pubmed:publicationType
Journal Article, Comparative Study