Linked Life Data

6988523

Source:http://linkedlifedata.com/resource/pubmed/id/6988523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1980-6-27
pubmed:abstractText
During prophylaxis with gentamicin and amoxicillin following surgical repair of a meningomyelocele in a newborn infant, a cerebrospinal fluid leak occurred and fever ensued. Cultures of ventricular fluid yielded Serratia marcescens resistant to several antibiotics, including gentamicin and tobramycin, but sensitive to amikacin. When therapy with amikacin was substituted for that with gentamicin and amoxicillin, cultures yielded an additional colony type of S. marcescens, which was antibiotic-sensitive but of the same serotype as the original isolate, that eventually replaced the original resistant organism. The resistant S. marcescens was shown to possess a 105 X 10(6)-dalton plasmid not observed in the sensitive variant. The sensitive variant may have originated by loss of the plasmid from the resistant organism, possibly by removal of the selection pressure of antibiotics, which favored the emergence of a bacterial population that did not harbor resistance plasmids during clinical therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
141
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
346-50
pubmed:dateRevised
2006-5-1
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Loss of an aminoglycoside resistance plasmid by Serratia marcescens during treatment of meningitis with amikacin.
pubmed:publicationType
Journal Article, Case Reports