Linked Life Data

6986382

Source:http://linkedlifedata.com/resource/pubmed/id/6986382

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1980-4-25
pubmed:abstractText
Permeabilized cells of Escherichia coli were used to examine the effect on RNA synthesis of guanosine 5'-diphosphate-3'-monophosphate (ppGp). Electrophoretic and hybridization analysis of bulk RNA demonstrated that ppGp selectively reduced the accumulation of both ribosomal and transfer RNAs. The experiments further suggested that the observed reduction in stable RNA accumulation resulted from a reduction in stable RNA chain initiation rather than an effect on elongation, processing, or maturation of stable RNA transcripts. In contrast, the expression of the lac Z gene was not affected by ppGp. These results suggest that ppG, a nucleotide produced in E. coli during the stringent response, could play a direct role in the stringent regulation of stable RNA synthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
255
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1830-3
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Regulation of ribosomal and transfer RNA synthesis by guanosine 5'-diphosphate-3'-monophosphate.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.