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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1980-4-17
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pubmed:abstractText |
A new combination of total lymphoid irradiation and cyclophosphamide was used prior to bone marrow transplantation in an attempt to achieve decreased rejection rates and graft-versus-host disease. Nine previously transfused patients with severe aplastic anemia received marrow from an HLA-identical, MLC-compatible sibling following this preparative regimen. There were no episodes of graft rejection, and only one patient developed graft-versus-host disease. Of the 9 patients, 7 (78%) are surviving with a median follow-up of 400 days. The excellent results of this pretransplant combination of total lymphoid irradiation and cyclophosphamide warrants application of this regimen to a larger series of patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
344-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6986180-Adolescent,
pubmed-meshheading:6986180-Anemia, Aplastic,
pubmed-meshheading:6986180-Bone Marrow Transplantation,
pubmed-meshheading:6986180-Candidiasis,
pubmed-meshheading:6986180-Child,
pubmed-meshheading:6986180-Child, Preschool,
pubmed-meshheading:6986180-Cyclophosphamide,
pubmed-meshheading:6986180-Graft Rejection,
pubmed-meshheading:6986180-Graft vs Host Reaction,
pubmed-meshheading:6986180-Humans,
pubmed-meshheading:6986180-Immunosuppression,
pubmed-meshheading:6986180-Infant,
pubmed-meshheading:6986180-Lymphoid Tissue,
pubmed-meshheading:6986180-Sepsis,
pubmed-meshheading:6986180-Transplantation, Homologous,
pubmed-meshheading:6986180-X-Rays
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pubmed:year |
1980
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pubmed:articleTitle |
Total lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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