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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1980-3-24
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pubmed:abstractText |
MBD has long been considered a childhood disorders. Recent research suggests that in some it persists into adult life and that at least one form is a consequence of reduced activity of dopaminergic systems in the brain. To test this hypothesis, three adults with "presumptive" MBD were given L-dopa plus carbidopa. Although overall this combination was less effective than stimulant medication, all the patients showed an initial response, and in one patient L-dopa seemed to potentiate the effect of methylphenidate. The authors point out that various dopamine agonists have different effects and that the possible potentiation effect is consistent with a dopaminergic hypothesis.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0002-953X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
137
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
73-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:6986093-Adult,
pubmed-meshheading:6986093-Attention Deficit Disorder with Hyperactivity,
pubmed-meshheading:6986093-Carbidopa,
pubmed-meshheading:6986093-Clinical Trials as Topic,
pubmed-meshheading:6986093-Drug Combinations,
pubmed-meshheading:6986093-Drug Evaluation,
pubmed-meshheading:6986093-Drug Synergism,
pubmed-meshheading:6986093-Female,
pubmed-meshheading:6986093-Humans,
pubmed-meshheading:6986093-Levodopa,
pubmed-meshheading:6986093-Male,
pubmed-meshheading:6986093-Methylphenidate
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pubmed:year |
1980
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pubmed:articleTitle |
An open clinical trial of L-dopa and carbidopa in adults with minimal brain dysfunction.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Case Reports
|