Linked Life Data

6984434

Source:http://linkedlifedata.com/resource/pubmed/id/6984434

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-4-7
pubmed:abstractText
The production of dead (apoptotic) cells by low doses of gamma-rays was independent of dose-rate between 0.27 and 450 cGy per min. The r.b.e. for doses of 14.7 MeV neutrons between 1 and 15 cGy was about 4, and for neutrons generated by bombarding a beryllium target with 600 MeV protons the r.b.e. was about 2.7. The dose-incidence curves for all three radiation types reached a plateau at about 3-4 dead cells per crypt section, and this occurred at about 20-40 cGy of gamma-rays. These curves are compatible with exponential survival of the cell population at risk (D0 of 24 cGy for gamma-rays, 6 cGy for 14.7 MeV neutrons and 9 cGy for 600 MeV neutrons). Since the dose-response is exponential there is no indication of much higher r.b.e. values at very low doses, a point of concern in radiation protection. The spatial distribution of dead cells in the crypt was similar after doses of gamma-rays or neutrons, indicating that the same population of target cells was affected in both cases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0020-7616
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Cell death (apoptosis) in the mouse small intestine after low doses: effects of dose-rate, 14.7 MeV neutrons, and 600 MeV (maximum energy) neutrons.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't