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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1983-1-7
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pubmed:abstractText |
Three subpopulations of surface immunoglobulin positive B cells were defined using monoclonal antibodies directed against IgM and IgD antigenic determinants and 2-color fluorescence activated cell sorter analysis: cells with a high density of sIgM and lacking sIgD (M++D-); cells with slightly less sIgM and dully positive for sIgD (M++D+), and cells with a low density of sIgM but brightly staining with anti-IgD (M+D+). In the spleen of two-week-old animals the M++D- cells are the more numerous. Their frequency declines during development in favor of the adult M+D+ cells. Because the densities of sIgM and sIgD on M+D+ cells are positively correlated it is hypothesized that immature M++D- cells first lose their sIgM and then reaquire sIgM together with sIgD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0065-2598
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
149
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-9
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:6983208-Aging,
pubmed-meshheading:6983208-Animals,
pubmed-meshheading:6983208-Antibodies, Monoclonal,
pubmed-meshheading:6983208-B-Lymphocytes,
pubmed-meshheading:6983208-Cell Differentiation,
pubmed-meshheading:6983208-Cell Separation,
pubmed-meshheading:6983208-Flow Cytometry,
pubmed-meshheading:6983208-Immunoglobulin D,
pubmed-meshheading:6983208-Immunoglobulin M,
pubmed-meshheading:6983208-Lymph Nodes,
pubmed-meshheading:6983208-Mice,
pubmed-meshheading:6983208-Mice, Inbred BALB C,
pubmed-meshheading:6983208-Rats,
pubmed-meshheading:6983208-Receptors, Antigen, B-Cell,
pubmed-meshheading:6983208-Spleen
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pubmed:year |
1982
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pubmed:articleTitle |
Fluorescence activated cell sorter analysis of murine B cell development.
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pubmed:publicationType |
Journal Article
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