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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1983-1-19
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pubmed:abstractText |
A homogeneous group of 53 Caucasian subjects with high-grade osteosarcoma (OS) was typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with 425 local controls, a trend towards an increase of HLA-B18 and decrease of HLA-B12 was observed. All the patients underwent amputation plus adjuvant chemotherapy and among the 29 patients with a follow-up longer than one year, 9 out of 10 subjects with HLA-A3 antigens developed metastases within a few months. None of the OS patients had the HLA-A3, B7 haplotype which is present in linkage-disequilibrium in the control population.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0001-2815
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:6983158-Adolescent,
pubmed-meshheading:6983158-Adult,
pubmed-meshheading:6983158-Bone Neoplasms,
pubmed-meshheading:6983158-Female,
pubmed-meshheading:6983158-Genetic Linkage,
pubmed-meshheading:6983158-HLA Antigens,
pubmed-meshheading:6983158-HLA-A3 Antigen,
pubmed-meshheading:6983158-HLA-B Antigens,
pubmed-meshheading:6983158-HLA-B18 Antigen,
pubmed-meshheading:6983158-HLA-B7 Antigen,
pubmed-meshheading:6983158-Humans,
pubmed-meshheading:6983158-Male,
pubmed-meshheading:6983158-Osteosarcoma,
pubmed-meshheading:6983158-Prognosis
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pubmed:year |
1982
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pubmed:articleTitle |
Frequency and prognostic value of HLA antigens in osteosarcoma patients.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
