Linked Life Data

6983008

Source:http://linkedlifedata.com/resource/pubmed/id/6983008

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1983-1-27
pubmed:abstractText
We describe a novel method for estimating the rate of destruction of the acetylcholine receptor (AChR) associated with the motor end-plate in the living animal. After the intramuscular injection of a nontoxic dose of alpha-bungarotoxin that had been monoiodinated with 125I (125I-BGT), the loss of radioactivity from the injected site is monitored by an externally positioned gamma counter. Two days after labeling, the decline of radioactivity in the injected muscle parallels the decline of end-plate specific radioactivity and can be used for the estimation of the degradation rate and half-life of end-plate AChR. Using this method, we measured AChR half-life in normal and in myasthenic rats and found a 2.5-fold decrease of AChR half-life in the myasthenic animals. This in vivo method has potential clinical applications.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0025-6196
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
758-64
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Estimation of degradation rate of acetylcholine receptor by external gamma counting in vivo.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't