Linked Life Data

6981797

Source:http://linkedlifedata.com/resource/pubmed/id/6981797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-12-2
pubmed:abstractText
Among 48 pieces of paired frog skins of Rana pipiens in Ringer's solution, 10 pieces showed a strictly monotone decrease in the short circuit current (SCC) following ouabain treatment (10(-4) M). In 9 cases a transient attenuation, and in 27 cases a distinct wave in the ebb of the SCC, was seen. In 2 instances, two waves were seen. Associated with the not-monotone events was a transient rise in electrical skin conductance. The reasons for these mixed skin responses are unknown. One possible reason is considered here: Early during the ouabain action, some of the Na+ entering from the mucosal side is trapped in the skin by electroneutral processes, in keeping with the already known fact that ultimately cellular KCl is partly replaced by NaCl. Computer assisted model studies show how monotone, and not-monotone "transepithelial" net Na+ flux curves can be generated. Essential conditions for the generation of not-monotone Na+ flux curves are: 1. Presence of two distinct "cellular", active Na+ pools in the model. 2. Presence of a loop pathway in which a principal "transepithelial Na+ transport compartment", and a constituent "Na+/K+ maintenance compartment", are connected to each other and to the "extracellular" compartment. The model, then, predicts under which kinetic conditions monotone and not-monotone transepithelial Na+ flux curves will be seen.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
394
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Kinetic studies on the effects of ouabain on Na+ fluxes in frog skin.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.