Linked Life Data

6981596

Source:http://linkedlifedata.com/resource/pubmed/id/6981596

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-12-2
pubmed:abstractText
MRL/Mp-lpr/lpr (lpr/lpr) mice develop a generalized lymph node (LN) hypertrophy reflecting the expansion of a T-cell subset that seems to act as an accelerating factor for autoimmunity. In an attempt to produce antisera specific for this T-cell subset, NZW rabbits and Lewis rats were hyperimmunized with cells from hypertrophied lpr/lpr LN. The resulting xenoantisera were extensively absorbed with lymphoid cells from the congenic MRL/Mp +/+ (+/+) strain. As assessed by complement-dependent microcytotoxicity and indirect immunofluorescence using flow cytofluorometry analysis, these xenoantisera reacted with 70-90% of the cells in the enlarged LN of 4-month-old lpr/lpr mice but only with 10-35% of the cells in the normal-sized LN of age-matched +/+ mice or of 2-month-old lpr/lpr mice. These xenoantisera which appear to identify surface antigens associated with the proliferating lpr/lpr T-cells may prove useful to investigate the mechanism by which these cells contribute to the autoimmune disease of lpr/lpr mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0165-2478
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-10
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Xenoantisera directed against the proliferating T-cells of MRL/Mp-lpr/lpr mice.
pubmed:publicationType
Journal Article