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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1982-10-12
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pubmed:abstractText |
A review of the literature concerning shigellosis treated with trimethoprim-sulfamethoxazole (TMP-SMZ) revealed comparative studies of 149 cases and noncomparative studies of 147 cases. Bacteriologic and clinical success rates were greater than or equal to 90% and TMP-SMZ compared favorably with alternative drug therapy. In the present study TMP-SMZ was given intravenously as initial therapy to 11 children hospitalized for severe shigella colitis. Bacteriologic and clinical responses were comparable to those observed with oral TMP-SMZ therapy. Pharmacokinetic studies revealed substantial differences between the responses of these children and those reported for adult patients; a higher ratio of SMZ to TMP (50:1) was found in children. It is concluded that TMP-SMZ is effective therapy for shigellosis and is the drug of choice in areas where ampicillin resistance is prevalent.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0162-0886
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
546-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6981170-Administration, Oral,
pubmed-meshheading:6981170-Carrier State,
pubmed-meshheading:6981170-Child, Preschool,
pubmed-meshheading:6981170-Drug Combinations,
pubmed-meshheading:6981170-Dysentery, Bacillary,
pubmed-meshheading:6981170-Female,
pubmed-meshheading:6981170-Humans,
pubmed-meshheading:6981170-Infant,
pubmed-meshheading:6981170-Infusions, Parenteral,
pubmed-meshheading:6981170-Kinetics,
pubmed-meshheading:6981170-Male,
pubmed-meshheading:6981170-Sulfamethoxazole,
pubmed-meshheading:6981170-Trimethoprim,
pubmed-meshheading:6981170-Trimethoprim-Sulfamethoxazole Combination
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pubmed:articleTitle |
Oral or intravenous trimethoprim-sulfamethoxazole therapy for shigellosis.
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pubmed:publicationType |
Journal Article,
Comparative Study
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