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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1982-9-17
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pubmed:abstractText |
Mouse L cells transfected with a genomic clone containing the H-2Ld gene (8-5 cells) were shown to function as targets for H-2Ld-specific cytotoxic T lymphocytes (CTL). The CTL-mediated lysis of 8-5 cells was shown to be H-2Ld specific by the use of (i) CTL with restricted reactivity, (ii) unlabeled target inhibiton, and (iii) monoclonal antibody inhibiton. We also demonstrated that 8-5 cells could function as targets for antibody-plus-complement-mediated cell lysis. Specificity was confirmed by using H-2Ld-specific monoclonal antibodies. These experiments demonstrate that the gene products of a major histocompatibility complex genomic clone can be functionally expressed in a foreign cell and can mediate immunologically specific cellular interactions.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-123002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-4271080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-4517664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-4547153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-6166874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-6895187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-6967857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-7058331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-7058332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-7191868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6980415-7217662
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3613-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6980415-Animals,
pubmed-meshheading:6980415-Antigens, Surface,
pubmed-meshheading:6980415-Complement Activation,
pubmed-meshheading:6980415-Cytotoxicity, Immunologic,
pubmed-meshheading:6980415-Gene Expression Regulation,
pubmed-meshheading:6980415-Genes,
pubmed-meshheading:6980415-Genetic Engineering,
pubmed-meshheading:6980415-H-2 Antigens,
pubmed-meshheading:6980415-Isoantibodies,
pubmed-meshheading:6980415-Major Histocompatibility Complex,
pubmed-meshheading:6980415-Mice,
pubmed-meshheading:6980415-T-Lymphocytes
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pubmed:year |
1982
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pubmed:articleTitle |
Specific recognition of the product of a transferred major histocompatibility complex gene by cytotoxic T lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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