| pubmed-article:698031 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:698031 | lifeskim:mentions | umls-concept:C0033497 | lld:lifeskim |
| pubmed-article:698031 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:698031 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:698031 | lifeskim:mentions | umls-concept:C0005508 | lld:lifeskim |
| pubmed-article:698031 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:698031 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:698031 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:698031 | pubmed:dateCreated | 1978-12-29 | lld:pubmed |
| pubmed-article:698031 | pubmed:abstractText | 1. A high performance liquid chromatographic method for the determination of propranolol in human plasma and blood has been developed and used to confirm that cumulation occurred during chronic oral administration, steady-state being achieved within 48 h of beginning 80 mg of the drug every 8 h. 2. The method was adapted to measure [H3]-propranolol and native drug in the same blood sample and was applied to determine simultaneously the disposition of i.v. ([H3]-propranolol) and orally (non-labelled) administered drug after single oral dose of 80 mg and when steady-state had been established on an 80 mg, 8-hourly regimen. 3. Using this approach it was possible to show that a reduced oral clearance at steady-state was associated with a smaller reduction in systemic (i.v.) clearance and no change in liver blood flow. A direct estimate of bioavailability was also possible and was found to be increased at steady-state compared with a single oral dose. 4. We conclude that the accumulation of propranolol during the attainment of steady-state is due to a reduction in intrinsic clearance, resulting in reduced presystemic hepatic extraction. | lld:pubmed |
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| pubmed-article:698031 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:698031 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:698031 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:698031 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:698031 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:698031 | pubmed:author | pubmed-author:ShandD GDG | lld:pubmed |
| pubmed-article:698031 | pubmed:author | pubmed-author:WoodA JAJ | lld:pubmed |
| pubmed-article:698031 | pubmed:author | pubmed-author:WilkinsonG... | lld:pubmed |
| pubmed-article:698031 | pubmed:author | pubmed-author:CarlMM | lld:pubmed |
| pubmed-article:698031 | pubmed:author | pubmed-author:VestalR ERE | lld:pubmed |
| pubmed-article:698031 | pubmed:author | pubmed-author:BelcherSS | lld:pubmed |
| pubmed-article:698031 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:698031 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:698031 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:698031 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:698031 | pubmed:pagination | 345-50 | lld:pubmed |
| pubmed-article:698031 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:698031 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:698031 | pubmed:articleTitle | Direct measurement of propranolol bioavailability during accumulation to steady-state. | lld:pubmed |
| pubmed-article:698031 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:698031 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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