| pubmed-article:6980125 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6980125 | lifeskim:mentions | umls-concept:C0678257 | lld:lifeskim |
| pubmed-article:6980125 | lifeskim:mentions | umls-concept:C0002131 | lld:lifeskim |
| pubmed-article:6980125 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6980125 | pubmed:dateCreated | 1982-9-24 | lld:pubmed |
| pubmed-article:6980125 | pubmed:abstractText | Several new aspects of the chemistry, genetics and cellular distribution of the murine Qa-2 alloantigen were apparent in an analysis of this antigen using monoclonal antibodies recognizing a Qa-2-like antigen called Qa-m2. Immunoprecipitation and sodium dodecyl sulfate polyacrylamide gel electrophoresis analysis identified the Qa-m2 alloantigen as a two-chain structure composed of a 39 000 dalton heavy chain and a 12 000 light chain which is probably beta 2-microglobulin; the heavy chain was readily distinguished from that of H-2. In addition, the expression of Qa-m2 alloantigens on the cell surface was found to be controlled by the H-2D gen with H-2Db strains carrying approximately 8-10 times greater amounts of Qa-m2 than strains carrying the H-2Dd or H-2Dq alleles. Finally, the Qa-m2 antigen, found predominantly on peripheral T cells, was present on only 10% of thymus cells. However, subpopulations of B cells (approximately 25% of all B cells) and bone marrow cells (15-20%) were also reactive. The monoclonal anti-Qa-m2 antibodies differed in their reactions from that reported for the conventional anti-Qa-2 sera, which must, therefore, be complex. The monoclonal antibodies may be useful reagents for functional analysis of T and B cell subpopulations. | lld:pubmed |
| pubmed-article:6980125 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980125 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6980125 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980125 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6980125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6980125 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6980125 | pubmed:month | May | lld:pubmed |
| pubmed-article:6980125 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:6980125 | pubmed:author | pubmed-author:McKenzieI FIF | lld:pubmed |
| pubmed-article:6980125 | pubmed:author | pubmed-author:HogarthP MPM | lld:pubmed |
| pubmed-article:6980125 | pubmed:author | pubmed-author:CrewtherP EPE | lld:pubmed |
| pubmed-article:6980125 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6980125 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:6980125 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6980125 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6980125 | pubmed:pagination | 374-9 | lld:pubmed |
| pubmed-article:6980125 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:6980125 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6980125 | pubmed:articleTitle | Description of a Qa-2 like alloantigen (Qa-m2). | lld:pubmed |
| pubmed-article:6980125 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6980125 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6980125 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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