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rdf:type |
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lifeskim:mentions |
umls-concept:C0007582,
umls-concept:C0011306,
umls-concept:C0018894,
umls-concept:C0039195,
umls-concept:C0175727,
umls-concept:C0591833,
umls-concept:C0871261,
umls-concept:C1518071,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
4
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pubmed:dateCreated |
1982-9-10
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pubmed:abstractText |
Enriched populations of Ia+ Fc receptor-negative dendritic cells were compared to other cell types for their stimulatory activity in primary mixed lymphocyte reactions to alloantigens and 2,4,6,-trinitrophenylated syngeneic cells. Dendritic cells were 20-100 times more effective than unfractionated splenocytes. A second cell type exhibiting strong stimulatory activity was an Ia+ Fc receptor-positive transiently adherent cell. Both types of stimulatory cells were only effective when able to produce the monokine interleukin 1. Thus glutaraldehyde-fixed cells were not stimulatory unless extraneous interleukin 1 was added. Stimulation of helper cells by either dendritic cells or Ia+ Fc receptor-positive cells resulted in the production of interleukin 2. The data are discussed in view of the recently formulated interleukin model as a minimal scheme to explain T-T cell interactions during the in vitro induction of cytotoxic T lymphocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2980
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6980123-Animals,
pubmed-meshheading:6980123-Antigens, Ly,
pubmed-meshheading:6980123-Cytotoxicity, Immunologic,
pubmed-meshheading:6980123-Female,
pubmed-meshheading:6980123-Histocompatibility Antigens Class II,
pubmed-meshheading:6980123-Immune Sera,
pubmed-meshheading:6980123-Interleukin-2,
pubmed-meshheading:6980123-Lymphocyte Cooperation,
pubmed-meshheading:6980123-Lymphocytes,
pubmed-meshheading:6980123-Male,
pubmed-meshheading:6980123-Mice,
pubmed-meshheading:6980123-Mice, Inbred A,
pubmed-meshheading:6980123-Mice, Inbred BALB C,
pubmed-meshheading:6980123-Mice, Inbred C57BL,
pubmed-meshheading:6980123-Mice, Inbred CBA,
pubmed-meshheading:6980123-Receptors, Fc,
pubmed-meshheading:6980123-Rosette Formation,
pubmed-meshheading:6980123-T-Lymphocytes
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pubmed:year |
1982
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pubmed:articleTitle |
T-T cell interactions during cytotoxic T cell responses. IV. Murine lymphoid dendritic cells are powerful stimulators for helper T lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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