Linked Life Data

6978230

Source:http://linkedlifedata.com/resource/pubmed/id/6978230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-6-24
pubmed:abstractText
1. 3-Methylcholanthrene administration increased levels of cytochrome P-450, benzo[a]pyrene hydroxylase activity and p-nitrophenetole O-deethylase activity in hepatic microsomes from the brown trout (Salmo trutta), leopard frog (Rana pipiens) and the garter snake (Thamnophis). The level of aminopyrine N-demethylase activity was increased in trout microsomes, but not in those from the frog, snake or rat. 2. The shift in the Soret maximum of the reduced carbon monoxide difference spectrum of cytochrome P-450 from 450 to 448 nm, which is observed when 3-methylcholanthrene is administered to rats, was not seen in microsomes from the trout, frog or snake. 3. Benzo[a]pyrene hydroxylase activity induced by 3-methylcholanthrene in the trout, frog and snake was inhibited by relatively low concentrations of SKF 525-A, but that induced in the rat was not. alpha-Naphthoflavone inhibited 3-methylcholanthrene-induced benzo[a]pyrene hydroxylase activity in the trout, frog and rat, but not in the snake. 4. 3-Methylcholanthrene induced an increase in the 455/430 nm peak height ratio of the reduced ethylisocyanide spectrum of microsomes in the rat and trout, but not in the frog or snake. 5. These observations (items 1--4 of the abstract) show that different species of cytochrome P-450 are induced by 3-methylcholanthrene in the four vertebrates. 6. Phenobarbital did not alter the components or the activities of hepatic monooxygenase systems in the trout, frog or snake, even though it was shown to accumulate in the livers of these vertebrates as readily as it does in the liver of the rat.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-0491
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
445-53
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Hepatic cytochrome P-450-dependent monooxygenase systems of the trout, frog and snake--III. Induction.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.